RING Finger Proteins
نویسندگان
چکیده
منابع مشابه
Ubiquitin ligase activities of Bombyx mori nucleopolyhedrovirus RING finger proteins.
The genome of Bombyx mori nucleopolyhedrovirus (BmNPV) is predicted to contain six RING finger proteins: IAP1, ORF35, IAP2, CG30, IE2, and PE38. Several other members of the RING finger family have recently been shown to have the ubiquitin-ligase (E3) activity. We thus examined whether BmNPV RING finger proteins have the E3 activity. In vitro ubiquitination assay with the rabbit reticulocyte ly...
متن کاملRING Finger Proteins Mediators of Ubiquitin Ligase Activity
ing that a small noncanonical RING finger protein, Rbx1 (also referred to as ROC1 and HRT1), is an essential component of SCF (Skp1/cullin-1/F-box protein) E3 complexes and that a complex containing Rbx1 and Until recently no specific function had been ascribed to Cdc53/cullin-1 (CUL-1) is sufficient to mediate ubiqui-the RING finger beyond a role in dimerization of several tination in vitro. R...
متن کاملMuscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo.
Muscle ring finger (MuRF) proteins have been implicated in transmitting mechanical forces to cell signaling pathways through their interactions with the giant protein titin. Recent evidence has linked mechanically-induced stimuli with the control of serum response factor activity and localization through MuRF2. This observation is particularly intriguing in the context of cardiac hypertrophy, w...
متن کاملFYVE-finger proteins
Many biochemical processes in the cell occur at the interface between the cytosol and an intracellular membrane. Vesicular trafficking, signal transduction and actin-regulated membrane rearrangements are examples of processes that require the recruitment of cytosolic proteins to a specific membrane in a reversible and regulated manner. Such a recruitment is in part accomplished through the bind...
متن کاملIdentification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.
The giant myofibrillar protein titin contains within its C-terminal region a serine-threonine kinase of unknown function. We have identified a novel muscle specific RING finger protein, referred to as MURF-1, that binds in vitro to the titin repeats A168/A169 adjacent to the titin kinase domain. In myofibrils, MURF-1 is present within the periphery of the M-line lattice in close proximity to ti...
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ژورنال
عنوان ژورنال: Cell
سال: 2000
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)00077-5